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KMID : 0606620070030040237
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Korean Journal of Fetal Medicine
2007 Volume.3 No. 4 p.237 ~ p.245
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Analysis of Cervical Colonization of Ureaplasma Urealyticum by PCR in Pregnant Women with Preterm Labor
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Cho Yong-Kyoon
Ko Ji-Kyung
Lee Chul-Min
Choi Hoon
Kim Bok-Rin
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Abstract
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Objectives: The purpose of this study was to determine the frequency of cervical colonization of U. urealyticum
in pregnant women with preterm labor using PCR and association between U. urealyticum colonization and preterm
birth and perinatal outcome.
Methods: Thirty-two pregnant women with preterm labor and intact membrane and thirty controls were included
in this study from December 2005 to July 2006 in Sanggyepaik hospital. Endocervical specimens were obtained
with cotton swab and U. urealyticum colonization was examined by PCR using specific primer.
Results: The prevalence of cervical U. urealyticum colonization was 43.5% (27/62). The positive rate of U.
urealyticum PCR in patients with preterm labor was higher than that in control but there was no statistical
significance (50% vs. 36.7%, p=0.29). Pregnant women with positive PCR for U. urealyticum had a significantly
higher rate of histologic chorioamnionitis (66.7% vs. 25%, p=0.031) and preterm birth (59.3% vs. 21.2%, p=0.003).
However, no significant differences in perinatal outcome were observed between pregnant women with positive
PCR and negative PCR for U. urealyticum.
Conclusions: Even though cervical colonization of U. urealyticum was not associated with preterm labor, it
was associated with histologic chorioamnionitis and risk for preterm birth.
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KEYWORD
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Ureaplasma urealyticum, Polymerase chain reaction, Preterm birth
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